Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex

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Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex

Owing to their great potentials in genetic code extension and the development of nucleic acid-based functional nanodevices, DNA duplexes containing HgII-mediated base pairs have been extensively studied during the past 60 years. However, structural basis underlying these base pairs remains poorly understood. Herein, we present five high-resolution crystal structures including one first-time rep...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2016

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gkw1296